Futures flat as investors weigh Fed's economic outlook

NEW YORK (Reuters) - Stock index futures pointed to a flat open on Wednesday as investors weighed comments from the Federal Reserve on the economy and banking sector against the recent five-day rally.

The Fed said most of the largest U.S. banks passed their annual stress test in a report that underscored the recovery of the financial sector but called out a few laggards, including Citigroup Inc.

The Fed also said late Tuesday it expects "moderate" growth over coming quarters with the unemployment rate declining gradually versus the "modest" growth the central bank said it expected in January.

Banks have been a leading component of the 11 percent rally in the S&P for the year, with the KBW Bank index up more than 20 percent and the S&P financial sector index up more than 18 percent.

"Certainly this is good news for the overall domestic financial system. It really shows banks have turned themselves around, raised capital significantly and are being much smarter and less aggressive about their capital positions, and that should give investors confidence in the system," said Tim Ghriskey, chief investment officer of Solaris Asset Management in Bedford Hills, New York.

"There is constant chatter about a correction ... given we've been pretty much since December on an uninterrupted rise," Ghriskey said.

Bank of America Corp climbed 2.6 percent to $8.71 in premarket trade. Citigroup Inc dropped 3.6 percent to $35.15.

S&P 500 futures edged up 0.4 point and were slightly above fair value, a formula that evaluates pricing by taking into account interest rates, dividends and time to expiration on the contract. Dow Jones industrial average futures rose 17 points, and Nasdaq 100 futures gained 2 points.

The increasing optimism on the U.S. economy helped boost the dollar, which hit an 11-month high against the yen and 1-month high versus the euro.

Data on Wednesday showed import prices rose in February on sharply higher petroleum costs, but there were few signs of underlying imported inflation pressures, and imported capital goods prices edged down 0.1 percent after advancing 0.4 percent in January.

Swiss drugmaker Roche Holding AG said it received a request for additional information from the Federal Trade Commission related to its $5.7 billion hostile bid for U.S. gene decoder Illumina Inc .

Gaming company Zynga Inc advanced 0.8 percent to $13.48 premarket after the online gaming company announced a $400 million secondary offering.

(Editing by Padraic Cassidy)

Source: http://news.yahoo.com/stock-index-futures-signal-mixed-wall-st-opening-094024485.html

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Detailed Gene Scan Might Help Guide Leukemia Treatment

WEDNESDAY, March 14 (HealthDay News) -- By analyzing gene mutations in patients with acute myeloid leukemia, researchers were able to more accurately predict which ones had the best chances of going into remission, and which ones would respond well to standard treatments or needed more aggressive treatment.

Doctors from Memorial Sloan-Kettering Cancer Center in New York City analyzed 18 genes from about 500 patients with acute myeloid leukemia (AML). AML is a cancer of the bone marrow, or the soft tissue that forms blood cells.

The patients had previously taken part in a clinical trial for a chemotherapy drug, daunorubicin, and researchers knew how everyone had fared in that study.

In the new analysis, the scientists used the latest gene-sequencing technology to determine what mutations were present in the cancer cells of the patients, and whether the presence of those mutations predicted how well people did.

They found that certain combinations of mutations were associated with both better or worse chances of survival, and that those genetic predictors could be used to determine whether patients would respond to the standard dose of daunorubicin or whether they should receive a higher, more aggressive dose of the drug.

Currently, some cancer hospitals already do a limited genetic analysis in leukemia patients to look for three mutations that are associated with a low or high risk of relapse, experts explained.

But about 60 percent of people fall into the intermediate category, said senior study author Dr. Ross Levine, an associate member in the Human Oncology and Pathogenesis Program at Sloan-Kettering. That leaves oncologists with a lot of uncertainty about how aggressively to treat those patients and what to tell them about their prognosis.

"If you know patients have a high chance of cure, you would pursue a standard therapeutic route," Levine said. "If you have a patient with a low chance of cure, you might consider more aggressive or investigational therapies."

Using the information from the more extensive analysis, about half of the patients who were in the intermediate risk could be put into a low- or high-risk category, Levine said.

"What we found was by studying the DNA of patients with leukemia and classifying all 500 patients, you could identify a set of mutations, which allows us to more accurately separate those at high risk of relapse, at intermediate risk of relapse and at low risk of relapse," Levine said. "Specifically, risk stratification with more extensive mutational profiling better predicts outcome than current classification schema."

The study is published online March 14 in the New England Journal of Medicine.

Dr. Lucy Godley, an associate professor of medicine at University of Chicago, who wrote an accompanying editorial, said the strengths of the study include the large number of patients, and that Levine and his colleagues used tissue samples that were already available from a prior study. That speeded up how quickly they could do their analysis and get answers that may benefit patients, she said.

Clinical trials take years to recruit patients, get approvals and follow patients long enough to determine how they did. With this study, the researchers already had all that information.

"What the Levine group did was to take samples from a completed study and ask a question with a modern, molecular eye," Godley said. "They found patients with certain mutations did better if they got a higher dose of the drug. What it implies is that the future of medicine is to molecularly fingerprint cancer patients, which we do a very little bit of right now."

As gene sequencing has become faster and less expensive, researchers are building up vast amounts of information about various mutations that are present in cancers, Levine said.

"The challenge we're all facing, both as cancer providers and cancer patients, is to try to understand how do we use these new, very innovative technologies which allow us to very rapidly categorize the different genes and mutations in the genes that are in cancers, to use that knowledge in the near term to actually help out patients," he said.

Next steps for the researchers include seeing if the findings hold up in other groups of patients, and then determining how to make the mutational analysis available to patients outside a research setting.

In a second study in the same journal, researchers from Washington University School of Medicine in St. Louis used DNA sequencing technology to map a series of mutations that transformed myelodysplastic syndrome into leukemia in seven patients.

Myelodysplastic syndrome occurs when blood cells produced in the bone marrow don't fully develop and immature cells crowd out healthy ones. Some patients can be treated with blood transfusions, but about one-third progress to acute myeloid leukemia, according to background information in the study.

In the study, researchers sequenced tumor cells from patients who had myelodysplastic syndrome, and then again later on, when disease had progressed to leukemia. They found that cancer cells evolved over time, gaining new mutations but also retaining certain mutations that likely first turned healthy cells into cancerous cells.

Drugs that target those original mutations that are present throughout the cancer would probably be most effective, the researchers said.

Researchers said to think of cancer as a tree.

"To kill a tree, you have to pull out the roots," senior study author Dr. Timothy Graubert said in a university news release. "If you only cut off a limb, it will just grow back. We're saying that to be effective, targeted cancer drugs probably need to attack mutations at the root of this disease."

More information

The U.S. National Cancer Institute has more on acute myeloid leukemia.

Source: http://news.yahoo.com/detailed-gene-scan-might-help-guide-leukemia-treatment-210408855.html

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Ben Flajnik: Kissing Hilaire Fouts and Alison McGlone After Split From Courtney Robertson


The Bachelor's Ben Flajnik adamantly denied - swore on his father's grave, no less - that he kissed other girls during his brief time apart from Courtney Robertson.

These photos clearly show him kissing Alison McGlone and Hilaire Fouts, however.

Here's the deal: Ben Flajnik and Courtney Robertson got engaged on the finale ... but he dumped her after seeing what a psycho she was throughout the season.

They were apart for a period in February, when the pics (below) were taken.

Courtney and Ben reconciled soon after, but he still swore up and down after The Bachelor finale that he didn't stray from her at any point. Why?

Ben Flajnik and Hilaire FoutsAlison McGlone and Ben FlajnikBen Flajnik, Alison McGlone

Ben kissed Hilaire Fouts (not pictured) after bar-hopping in San Francisco on February 17. Ben was seen kissing an unidentified woman (red pants) after the bars closed.

Doesn't look like the way you kiss a "friend," does it? Ben was later seen being escorted home by another woman (Fouts), who left the next morning in the same clothes.

The following night, Flajnik was seen on a romantic late night dog walk with another woman, Alison McGlone (above, center and right) whom he could be seen kissing.

Note that there is ass-grabbing going. Not "friend" material. Early the next day, Alison McGlone was seen leaving his house and walking home ... in the same clothes.

Again, he and Court had split up during this window. But he may have also blatantly lied on TV. Pure celebrity gossip fodder, perhaps. But that doesn't mean it's false.

It all makes you wonder ... will Ben and Courtney last?

[Photos: Pacific Coast News]

Source: http://www.thehollywoodgossip.com/2012/03/ben-flajnik-kissing-hilaire-fouts-and-alison-mcglone-after-split/

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Staying in a Holiday Home Europe is Worth the Expense

Going on holiday should be a relaxing time for the family where they can enjoy their days away from their daily life. That is why many people who take a vacation in Europe with the family would rather stay in one of the fabulous holiday homes Europe instead of a hotel room. When deciding upon staying in a hotel room versus any number of the beautiful holiday homes Europe most tourists will choose the holiday home. The problem is that many tourists do not believe that they will find any of the holiday homes Europe within their budget.

However, if the tourist researched everything that their potential hotel has to offer and compared it to any of the holiday homes Europe in the area, there would be an unequal advantage. All the amenities that a hotel has to offer is nothing compared to the holiday homes Europe. A stay at a holiday home in Europe will mean that the tourist, and their family will be able to enjoy the privacy of having the whole house to themselves. Along with the privacy of the home, most holiday homes Europe have a private pool. This is especially fun for the children in the family because that means they will not be disturbing any as they splash around in the water.

One of the other ideal amenities that the holiday homes Europe has to offer is that their guests are able to cook their own food, so they do not have to be concerned about not liking what is on the menu at the hotel restaurant. The best part about renting a holiday home in Europe for the adults is that when they put their children to bed they can relax in front of the fireplace and not have to be concerned if their child wakes up in the night. The convenience of staying in a holiday home in Europe is always worth the extra money so be sure to add it into the budget.


Source: http://wanderingpurplediva.com/2012/03/staying-in-a-holiday-home-europe-is-worth-the-expense/

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Personal cloud will replace PC by 2014: Gartner | Firstpost

Bangalore:?The reign of the personal?computer as the sole corporate access device is coming to a?close, and by 2014, the personal cloud will replace the
personal computer at the centre of users? digital lives,?according to technology researcher Gartner, Inc.

Gartner analysts said the personal cloud will begin a new era that will provide users with a new level of flexibility?with the devices they use for daily activities, while?leveraging the strengths of each device, ultimately enabling
new levels of user satisfaction and productivity.?However, it will require enterprises to fundamentally?rethink how they deliver applications and services to users,?a Gartner statement said.

Gartner analysts said the personal cloud will begin a new era that will provide users with a new level of flexibility with the devices they use for daily activities. Reuters

?Major trends in client computing have shifted the market?away from a focus on personal computers to a broader device?perspective that includes smartphones, tablets and other?consumer devices,? said Steve Kleynhans, research vice-president at Gartner. ?Emerging cloud services will become the?glue that connects the web of devices that users choose to?access during the different aspects of their daily life.?

The past two years have been a whirlwind in the client?computing space, leaving many enterprises asking what comes?next and what the environment will look like in five years,?it said.

?Many call this era the post-PC era, but it isn?t really?about being ?after? the PC, but rather about a new style of?personal computing that frees individuals to use computing in?fundamentally new ways to improve multiple aspects of their
work and personal lives,? Kleynhans said.

Several driving forces are combining to create this new?era. These megatrends have roots that extend back through the?past decade but are aligning in a new way, Gartner added.

PTI

Source: http://www.firstpost.com/tech/personal-cloud-will-replace-pc-by-2014-gartner-241326.html

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Annan feels Syria mission "on right track": spokesman

BEIRUT (Reuters) - U.N.-Arab League envoy Kofi Annan feels his Syria mediation mission is on track even though violence still raged as he held talks with President Bashar al-Assad, his spokesman said on Monday.

Annan twice met Assad in Damascus, as well as opposition figures, at the weekend and saw Qatari leaders in Doha on Monday before heading to Turkey.

Before he went to Syria, he held separate talks with the Arab League chief and the foreign ministers of Russia and Saudi Arabia in Cairo, his spokesman Ahmad Fawzi said.

"This is the beginning of a process and the joint special envoy feels the process is on the right track," Fawzi told Reuters by telephone from Qatar.

"He has left a set of concrete proposals with Bashar on a cessation of hostilities, humanitarian access and political dialogue, and expects to hear from him shortly," Fawzi said.

"He is concerned that the fighting and the killing seem to be continuing while he is trying to put an end to it and while he is trying to talk to Bashar," he said.

Scores of people were reported killed in Syria during Annan's visit, when the military assaulted the rebel-held city of Idlib in the northwest. State media and opposition activists also said dozens of civilians were slain in Homs but gave conflicting accounts of who was responsible.

After his "comprehensive and candid" talks with Assad, Annan said it would be hard to reach a deal but he remained optimistic.

"The situation is so bad and so dangerous that all of us cannot afford to fail," he told reporters in Damascus.

Annan plans to pursue contacts with opposition factions, including the Syrian National Council, the National Coordination Body, the Free Syrian Army and others, and will encourage them to create a unified opposition front.

"It will be a step by step process. We have to get the opposition on board. We have to get the opposition parties to unify under one umbrella," Fawzi added. "And then we have to convince the government to come and meet them in whichever venue he (Annan) proposes."

Annan, who is based in Geneva, also wants foreign powers that have influence with the Syrian government or opposition to use their good offices to promote his mission.

"He has made proposals that he feels will push the process forward," Fawzi said.

Source: http://news.yahoo.com/annan-feels-syria-mission-track-spokesman-120322489.html

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Archery Contest

Hi Everybody! Again!

-waves-

All right, as should be obvious, this is a private contest. If you weren't invited, you are welcome to watch, gasp in awe and choose somebody to cheer on. However, please don't jump in and start shooting. Enjoy!

-----------------

The night was cold, but calm. Outside anyways. Inside the barracks common room it was a scene of nearly controlled chaos as a regiment of people who had been cooped up away from everything that they were used to for a long period of time tried to blow off a little steam. There was boasting and bragging and card games. In one corner there was a tournament of arm wrestling going on, while in the other corner a couple of amateur musicians with more enthusiasm than skill tried to provide a bit of entertainment. It wasn?t much, but they were enjoying themselves. Mageria smiled at that; it was good to see things getting back to normal.

Somewhere around midnight, the boasting about weaponry skills started. While for the most part her people were smart enough that they didn?t haul out their weapons right then and there, two of her archers were about to start trick shots right then and there before she stepped in. Mageria fought a smile down as the two archers looked shame faced when she caught them; trying unsuccessfully to look repentant.

?Well, I suppose that we do need something to do, don?t we?? Mageria looked around at everybody and realized that a bit of healthy competition would do everybody a world of good.
?Right then. Tomorrow, you?ll all get the chance to show off. Until then; you need to behave.? She looked around at those who were her guests. ?Everybody is welcome; we?ll come up with some sort of prize or something. This will be a friendly contest, so no taking out your rivals before we start.? She rolled her eyes at the chorus of groans that met her announcement.

The next day dawned crisp and clear. Mageria had spent a little while figuring out how to properly test the skills of her people and her guests and believed that she had come up with something that would be a proper test. Facing the line of contestants, she grinned and cleared her throat.
?All right then. This is going to be in a series of three tests. The first one,? she gestured at a line of targets set up across the clearing. ?Is going to be a standard test. Those that manage to pass this test, shall go on to the next level. Shall we begin??

The line of archers was at one end of a clearing, about seven or eight men and women. At the other end of the clearing was a series of targets, standard bullseye types, but in varying sizes. Some of them were as big as dinner plates, while a couple of them were no bigger than the palm of her hand.
?Oh, and one more thing. Whoever wins, gets a bit of a prize.? Mageria held up a quiver in explanation. Jones, who was a fairly skilled leather worker, had made it to while away the long night hours. It was stamped and stained with a raven stooping down from the middle of the night sky, full moon shining down. It was a work of art; one that he had donated as the prize for the contest. It was also filled with a new set of arrows, all of them fletched with the black feathers that they had been desperate to get rid of.

?And . . . let?s begin!?

Source: http://feedproxy.google.com/~r/RolePlayGateway/~3/7EgcHS603eo/viewtopic.php

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Software Development Career - essay writing companies with jobs ...

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Effective Ways to Get the Most Out of Your Autoresponder | Apricot ...

Most internet marketing professionals know how powerful autoresponders are when it comes to building an online business. When you have an autoresponder, you don?t have to do a thing because your emails will all get sent out automatically. In a way, it works like your personal assistant taking care of all your email marketing needs without you having to do anything, except the initial setup. But you won?t get the most out of your autoresponder unless you go about it the right way. Being creative here is important because ultimately what matters is how you?re getting out of your efforts. The tips you?re about to learn about will give you all you need to get the most from your autoresponder and its effect on your target audience. There are so many different aspects of both online and offline business that have the potential for overwhelming anyone. All the old vets of internet marketing who pioneered Sonic List Builder went through that and know the deal. One very common strategy is hiring freelancers, but for most that is only possible with existing business profits. What you should strive for is combining as many effective approaches as possible. It is never a good idea to run straight ahead before you really know the ins and outs of any technique or approach. The simple reason is it will make you a better business person because you will know what is good and bad work from your freelancers.

Publish high quality newsletters that go out automatically by using your autoresponder. You could use many autoresponder services like Aweber or GetResponse that can help you follow up with your target audience with your newsletter that you?ve already created in advance. By running a targeted newsletter you actually increase the chances of building and growing your credibility with your subscriber base. Besides what you may think, it?s not that hard to send out a newsletter each month or even twice a month. What?s more, because everything goes out automatically, you can even send it out on a weekly basis.

When you get an email address, it provides you with an excellent chance to follow up with them so that you can tell them about your products that they didn?t buy previously.

This can also be called ?drip? or ?follow up? marketing. There have been countless studies that prove that seven times is the prime number that prospects must be exposed to a product before they buy it. By using an autoresponder you can follow up with your prospects and with each email, persuade them to buy the product and show them how beneficial it is for them. Most of the time you?ll find that people weren?t interested in something the first time around but that they buy because you managed to follow up with them. If you were to do this with every prospect you had, you would find it very frustrating, but autoresponders make it much easier because things are automated for you. We do know people in business who seem to have a closed mind when it comes to something new such as a method for marketing or advertising, and they are leaving a lot of money behind as a result. Naturally, we are talking about ideals because we know most people will have difficulty possessing such an open mind. For ages, people have been encouraging others about Lifetime Video Profits because their results were so good. All businesses have to set their limits concerning how they want to promote themselves, and that fact is not lost on us.

If you are impatient and fail to do your due diligence, then you are obviously taking certain risks with your time and possibly money. There really are a lot of people, we assume based on what we have read, who just blindly buy things they think will work great and maybe never even try them. Online marketers who are impatient or simply do not know are at the greatest risk. What we are writing about in this article is well known and without question, but you still really have to discover more in order to get the most out of it. That is a habit worth developing because at some point along the line it will serve you very well.

Another great idea is to provide your subscribers with value on a daily basis. That?s right, people don?t care about daily emails as long as those emails give them information or techniques they can use right away. There is so much information you can share in this manner. For example, you may tell them some news about the industry you?re working within, or you may share something good that happened to your business lately. As long as you think creatively, you will find it easy to do. It?s easy because you?ll just update your autoresponder whenever you get this type of information. In conclusion, the above article gives us a clear understanding on how important it is to be creative when using an autoresponder. There are many internet marketers who don?t reach their full potential because they don?t realize that their autoresponders can be used in a number of different ways, not just one or two. If you want to stay ahead of the competition, make sure you use an autoresponder for your email marketing efforts. Even if a method seems really hard, see if you can make it a little simpler by employing an autoresponder. Remember, the more time you save, the more money you make. The methods involving How to lose the belly fat we have just talked about are proven to bring the results you need to add positive growth to your business. We urge you to also think about how you look at your business and think about it, as well. There are all kinds of expressions thrown around such as a success mindset, for instance, and there is a great deal of credence in that concept. We tend to believe that only a certain percentage of people will realize how important attitude and belief are and will actively address it. There are so many ways that restrictive thinking and behavior will impede success, and the cool thing is that you can reverse that trend. You always have a choice in all things; at least that is our guiding principle.

Source: http://www.apricot2004.net/2012/03/10/effective-ways-to-get-the-most-out-of-your-autoresponder/

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